Frequently Asked Questions
Your fertility journey clarified. Answers to common concerns.
After Transfer & TWW
How can I cope with the anxiety of the Two Week Wait?
The wait is famously difficult. Distract yourself with light hobbies, binge-watch a show, practice meditation, stay off Google symptom-checking, and lean heavily on your support system or a fertility counselor.
How soon can I try again if the cycle fails?
If you have frozen embryos, you can often start an FET in your next menstrual cycle. If you need a new egg retrieval, doctors usually recommend waiting 1 to 2 months for your ovaries to rest.
What happens if the pregnancy test is negative?
You will be instructed to stop your hormonal medications, and a menstrual period should begin within a few days. You will then schedule a follow-up with your doctor to review the cycle and plan next steps.
When is the first ultrasound after a positive test?
The first ultrasound is usually scheduled between 6 to 7 weeks of pregnancy (about 3-4 weeks after the transfer) to confirm the heartbeat and rule out ectopic pregnancy.
What happens if the pregnancy test is positive?
You will repeat the blood test 48 hours later to ensure the hCG levels are doubling properly. You will also continue all progesterone and estrogen medications until 10-12 weeks.
Why shouldn't I use a home pregnancy test?
Home tests can yield false positives if the hCG 'trigger shot' is still in your system, or false negatives if tested too early. The blood test is the only accurate method.
When can I take a pregnancy test?
Your doctor will schedule a beta hCG blood test exactly 9 to 14 days after the transfer. This is the only definitive way to confirm pregnancy.
Are cramping and spotting normal after transfer?
Yes, mild cramping and light spotting are very common and can be caused by the catheter passing through the cervix or by the embryo implanting into the uterine wall.
What should I avoid after embryo transfer?
Avoid strenuous exercise, heavy lifting, hot tubs, saunas, heating pads on the abdomen, swimming, and intercourse until you receive your pregnancy test results.
Do I need bed rest after the embryo transfer?
No. Strict bed rest is an outdated concept and does not improve success rates. Most doctors recommend 24 hours of relaxation, followed by a return to normal, light activities.
Egg Freezing & Donor Options
Is surrogacy an option with IVF?
Yes. If a woman cannot carry a pregnancy safely (due to uterine issues or health conditions), her embryos can be transferred to a gestational carrier (surrogate). Legal regulations vary by region.
What is embryo donation?
Embryo donation occurs when couples who have completed their IVF families donate their remaining frozen embryos to another individual or couple facing infertility.
Can I use a known donor?
Yes, many women use a sister, cousin, or close friend as an egg donor, provided the donor passes all necessary medical and psychological screenings.
Who are the egg donors?
Egg donors are typically healthy young women (usually under 30) who undergo rigorous medical, genetic, and psychological screening before being approved to donate.
Will a baby from a donor egg look like me?
You can select an egg donor based on physical characteristics, education, and background to match your own. Epigenetics also shows that the pregnant mother's uterine environment profoundly shapes the baby's gene expression.
When should I consider using donor eggs?
Donor eggs are recommended for women over 43, women with premature ovarian failure, or those who have had multiple failed IVF cycles due to poor egg quality.
Is freezing embryos better than freezing eggs?
Historically, embryos survived thawing better than eggs. However, with modern vitrification, egg survival rates are excellent. Embryos are still slightly more robust, but freezing eggs preserves reproductive autonomy for single women.
How many eggs should I freeze?
Doctors generally recommend freezing 15-20 eggs for women under 35 to have a high probability of one future live birth. Women over 35 may need to freeze more.
How long can eggs remain frozen?
Indefinitely. Eggs are flash-frozen using vitrification and stored in liquid nitrogen at -196°C. They do not degrade over time and can be used decades later.
What is the best age to freeze my eggs?
The optimal age to freeze eggs is between 27 and 34. Freezing eggs before age 35 ensures high chromosomal quality and yields a better quantity of eggs per cycle.
Male Factor Infertility
How is a semen sample collected for IVF?
The sample is typically collected via masturbation in a private room at the clinic on the morning of the egg retrieval to ensure the sperm is fresh for fertilization.
Does varicocele affect IVF?
A varicocele (enlarged vein in the scrotum) raises testicular temperature and damages sperm. Repairing a varicocele surgically prior to IVF can significantly improve sperm quality.
What is MACS for sperm sorting?
Magnetic-Activated Cell Sorting (MACS) uses magnetic nanoparticles to filter out damaged or dying sperm cells, leaving only the healthiest sperm for fertilization.
What is PICSI?
Physiological ICSI (PICSI) is an advanced method of selecting sperm for ICSI. It uses a hyaluronic acid gel to select mature, high-quality sperm that bind to the gel, mimicking natural selection.
Does male age affect IVF success?
Yes. While men produce sperm their whole lives, sperm DNA fragmentation and the risk of genetic mutations increase significantly in men over the age of 45, which can lower IVF success.
How can men improve sperm quality for IVF?
Men can improve sperm quality by taking antioxidants (CoQ10, Zinc, Vitamin C), losing weight, wearing loose underwear, avoiding hot tubs, quitting smoking, and reducing alcohol consumption.
What is DNA Fragmentation in sperm?
DNA fragmentation refers to breaks in the genetic material inside the sperm. High fragmentation can lead to poor embryo development and miscarriage, even if the sperm count is normal.
What if there is zero sperm in the ejaculate?
Azoospermia (zero sperm) can often be treated. A urologist can perform a surgical procedure (TESE or PESA) to extract sperm directly from the testicles for use in IVF.
When is ICSI recommended?
ICSI is recommended for low sperm count, poor sperm motility, high abnormal morphology, previously failed fertilization, or when using surgically retrieved or frozen sperm.
What is ICSI?
Intracytoplasmic Sperm Injection (ICSI) is a technique where a single, healthy sperm is selected and injected directly into the center of the egg, bypassing the need for the sperm to swim.
Success Rates & Risks
Can adenomyosis cause IVF to fail?
Adenomyosis (endometrial tissue growing into the uterine muscle) can lower implantation rates. Doctors often treat it with several months of Lupron suppression before an embryo transfer.
Does endometriosis reduce IVF success?
Severe endometriosis can damage egg quality and create a toxic pelvic environment. However, IVF is the most successful treatment for women with endometriosis because it bypasses the pelvic cavity.
Can fibroids affect IVF success?
Yes, particularly submucosal fibroids that bulge into the uterine cavity. They can physically block implantation or alter blood flow to the lining, and often need surgical removal prior to transfer.
What is recurrent implantation failure?
This is when a patient has had 3 or more high-quality embryos transferred in multiple cycles without achieving a pregnancy. It requires deeper investigation into uterine or immune factors.
Does a high AMH guarantee IVF success?
No. A high AMH (Anti-Mullerian Hormone) means you will likely produce many eggs, but it does not guarantee high egg quality or genetic normality.
Can IVF cause ectopic pregnancies?
Yes, though the embryo is placed in the uterus, there is a small 2-5% chance it can migrate into a fallopian tube and cause an ectopic pregnancy.
Does IVF increase the risk of cancer?
Decades of extensive research show no significant link between fertility medications used in IVF and an increased risk of breast or ovarian cancer.
What are the risks of IVF?
Risks include multiple pregnancies (if transferring more than one embryo), OHSS, ectopic pregnancy, and the emotional/financial toll of failed cycles.
Why does IVF fail?
The most common reason for IVF failure is chromosomal abnormality in the embryo. Other reasons include poor uterine lining receptivity, immune issues, or poor egg quality.
What is a good IVF success rate?
Success rates depend heavily on age. For women under 35, a 40-50% live birth rate per transfer is excellent. Over 40, the rate drops to 10-15% with their own eggs.
The IVF Process & Timeline
Why do I need progesterone shots or suppositories?
During IVF, natural progesterone production is often suppressed. Supplemental progesterone is vital to thicken the uterine lining and sustain the pregnancy until the placenta takes over at 10 weeks.
What is Laser Assisted Hatching?
It is a lab technique where a microscopic laser makes a tiny hole in the embryo's outer shell to help it 'hatch' and implant into the uterine wall more easily.
Do frozen embryos survive the thaw?
Yes, modern fast-freezing techniques (vitrification) are incredibly effective. Over 95% of high-quality embryos survive the thawing process completely intact.
What is a Frozen Embryo Transfer (FET)?
An FET is a cycle where an embryo created and frozen in a past cycle is thawed and transferred into the uterus. This allows the woman's body time to recover from the stimulation medications.
How many embryos will be transferred?
To reduce the risk of high-risk multiple pregnancies (twins/triplets), most clinics strongly recommend Single Embryo Transfer (SET), especially if the embryo is genetically tested.
How is the embryo transfer done?
The transfer is a simple, painless procedure similar to a pap smear. Using ultrasound guidance, a soft catheter is passed through the cervix, and the embryo is gently placed into the uterus. No anesthesia is required.
What is a blastocyst?
A blastocyst is an embryo that has developed for 5 or 6 days and contains roughly 100-200 cells. Blastocysts have a much higher implantation rate than Day 3 embryos.
When does fertilization happen?
Fertilization occurs in the laboratory on the same day as your egg retrieval. The embryologist will combine the eggs and sperm within a few hours of the procedure.
What is OHSS?
Ovarian Hyperstimulation Syndrome (OHSS) is a medical condition where the ovaries become swollen and fluid leaks into the abdomen. It is closely monitored for and is rare with modern IVF protocols.
How long is the recovery after egg retrieval?
Most women take the rest of the day off to sleep off the anesthesia. You may experience mild cramping and bloating for a few days, but can usually return to work the next day.
Will I be awake during egg retrieval?
Most clinics use conscious sedation (propofol), meaning you will be entirely asleep and feel no pain, but you will wake up very quickly after the procedure.
How is the egg retrieval performed?
It is a minor surgery taking 15-20 minutes. Under mild anesthesia, the doctor uses an ultrasound-guided needle passed through the vaginal wall into the ovaries to extract the follicular fluid containing the eggs.
What is the 'trigger shot'?
The trigger shot is a final injection of hCG or Lupron given exactly 36 hours before egg retrieval. It triggers the final maturation and release of the eggs.
Where do I inject the IVF medications?
Most stimulation medications are injected subcutaneously (into the fat layer just under the skin) in the abdomen. Progesterone is usually injected intramuscularly into the buttocks.
What are the daily injections for?
The daily injections (gonadotropins) are hormones that stimulate your ovaries to mature multiple eggs simultaneously, rather than the single egg developed in a natural cycle.
Preparation & Lifestyle
How important is sleep during IVF prep?
Crucial. Aim for 7-9 hours of quality sleep per night. Melatonin regulates circadian rhythms and has antioxidant properties that benefit ovarian follicles.
Is it safe to have intercourse during IVF?
Intercourse is usually fine early in the cycle, but you will be advised to abstain near the egg retrieval (due to discomfort and risk of multiple natural pregnancies) and immediately following the embryo transfer.
Can I dye my hair during IVF?
Most doctors consider hair dye safe, but to be overly cautious, many women prefer to avoid chemical treatments during stimulation and after the embryo transfer.
How long should the male partner abstain before giving a sample?
Generally, an abstinence period of 2 to 5 days is recommended before providing a semen sample for egg retrieval. Longer abstinence can decrease sperm motility.
Does acupuncture help IVF?
Many women find acupuncture helpful for managing stress and improving blood flow to the uterus, though scientific evidence on its direct impact on live birth rates is mixed.
Should I stop taking my regular medications?
Never stop medications without consulting your doctor. Provide a complete list of all prescriptions and over-the-counter drugs to your fertility specialist so they can check for contraindications.
Can I travel during my IVF cycle?
Travel is very difficult during the stimulation phase due to required clinic visits every 2-3 days for ultrasounds and blood work. It is best to stay near your clinic.
Does BMI affect IVF success?
Yes. Being significantly underweight or overweight can alter how your body absorbs hormones and can lower success rates. A healthy BMI is optimal for IVF.
How much caffeine is safe during IVF?
Limit caffeine to under 200mg per day (about one 12oz cup of coffee). Some doctors recommend eliminating it entirely during the stimulation phase and after transfer.
Can I drink alcohol during IVF?
It is highly recommended that both partners stop drinking alcohol before and during the IVF cycle, as it can negatively impact egg and sperm quality.
Does stress cause IVF to fail?
While extreme chronic stress is unhealthy, normal anxiety surrounding the IVF process will not cause a cycle to fail. However, managing stress through therapy or mindfulness can improve your experience.
Can I exercise during IVF stimulation?
Light exercise like walking or gentle yoga is fine. However, high-impact activities (running, heavy lifting, or deep twisting) should be avoided to prevent ovarian torsion as your ovaries enlarge.
Should I take supplements before IVF?
Yes, Folic Acid is essential. Many doctors also recommend CoQ10 (for egg energy), Vitamin D, and Omega-3 fatty acids. Always consult your doctor before starting supplements.
What is the best diet for IVF?
The Mediterranean diet—rich in whole grains, lean proteins, healthy fats (like olive oil and avocados), and fresh vegetables—is considered the gold standard for fertility.
How should I prepare my body for IVF?
Start preparing 3 months in advance by taking a prenatal vitamin, adopting a healthy anti-inflammatory diet, quitting smoking, and reducing alcohol and caffeine intake.
Costs & Financials
Why are IVF costs so high?
The cost reflects the highly specialized embryology laboratory, advanced incubators, imported culture media, and the expertise of reproductive endocrinologists and embryologists.
Is a refund guaranteed if IVF fails?
Some clinics offer 'shared risk' or multi-cycle refund programs, but standard single IVF cycles do not come with refunds if a pregnancy is not achieved.
What is the cost of Genetic Testing (PGT)?
PGT is an advanced add-on. It typically costs around ₹15,000 to ₹25,000 per embryo tested.
Do you offer financing or EMI options for IVF?
Many top fertility clinics, including ours, partner with medical financing companies to offer zero-percent or low-interest EMI plans to make treatment more affordable.
How much does embryo freezing (vitrification) cost?
Freezing your embryos and the first year of storage typically costs around ₹25,000 to ₹40,000, with an annual maintenance fee thereafter.
Is it cheaper to do a Frozen Embryo Transfer (FET)?
Yes. If you have frozen embryos from a previous cycle, an FET is significantly cheaper than starting a full fresh IVF cycle because it skips the stimulation and egg retrieval phases.
Are there hidden costs in IVF?
Couples should ask about costs for preliminary blood tests, freezing extra embryos, ICSI, blastocyst culture, and subsequent frozen embryo transfers, which are often not in the 'base package'.
Does health insurance cover IVF?
Most standard health insurance policies in India do not cover IVF. However, some corporate policies and specialized health plans are beginning to offer partial coverage.
Are IVF medications included in the base cost?
Typically, no. Injectable fertility medications are usually billed separately and can add ₹50,000 to ₹1,00,000 to the total cost.
What is the average cost of IVF?
The cost varies greatly by clinic and required procedures, but a standard cycle in India generally ranges from ₹1,20,000 to ₹2,50,000, excluding medications.
General IVF & First Steps
How many times should I try IVF?
This is a personal and financial decision. Statistically, the cumulative success rate rises significantly over 3 to 4 cycles, but your doctor will advise based on your specific prognosis.
Does having one child mean I won't need IVF for the second?
Not necessarily. Secondary infertility (difficulty conceiving after having a child naturally) is common and can be caused by age, new medical conditions, or changes in sperm quality.
What is a 'chemical pregnancy' in IVF?
A chemical pregnancy is a very early miscarriage that happens shortly after implantation. A positive pregnancy test occurs, but the pregnancy is lost before it can be seen on an ultrasound.
Can I do IVF with donor sperm?
Yes, IVF is commonly performed using rigorously screened donor sperm from a sperm bank, which is often used by single mothers, same-sex couples, or in cases of severe male infertility.
What is an embryo grading system?
Embryologists grade embryos based on their physical appearance (morphology) under a microscope, looking at cell division rate and symmetry to choose the best embryo for transfer.
What happens if no eggs fertilize?
Total fertilization failure is rare, especially with ICSI. If it occurs, your doctor will review the cycle to determine if it was an egg quality or sperm issue and adjust the protocol for the next attempt.
How many eggs are usually retrieved during IVF?
The ideal number of eggs is typically between 10 and 15, but this varies wildly depending on a woman's age, ovarian reserve, and response to medication.
Can I do IVF if my tubes are tied?
Yes! Because IVF bypasses the fallopian tubes entirely by retrieving eggs directly from the ovaries, it is an excellent option for women with tied or blocked tubes.
Do IVF babies have more health problems?
The vast majority of IVF babies are perfectly healthy. There is a slightly increased risk of premature birth and low birth weight, often linked to multiple pregnancies (twins).
What are the common side effects of IVF medications?
Common side effects include mood swings, headaches, hot flashes, bloating, breast tenderness, and mild bruising at the injection site.
Can I choose the gender of my baby with IVF?
Yes, through PGT-A testing, the sex chromosomes of the embryo can be identified before transfer. However, gender selection regulations vary by country. In India, gender selection is strictly illegal under the PC-PNDT Act.
How painful is the IVF process?
Most women experience mild discomfort, bloating, and bruising from injections. The egg retrieval is done under sedation and is generally not painful, though mild cramping afterward is common.
Does IVF guarantee a baby?
No. While IVF is the most successful fertility treatment, it does not guarantee a pregnancy. Success depends on age, egg/sperm quality, and the uterine environment.
Can IVF prevent genetic diseases?
Yes. Preimplantation Genetic Testing (PGT) can be performed on embryos before transfer to screen for known genetic disorders and chromosomal abnormalities.
What is the difference between IUI and IVF?
IUI involves placing sperm directly into the uterus during ovulation. IVF involves retrieving eggs, fertilizing them in a lab, and transferring the resulting embryo into the uterus.
How long does one IVF cycle take?
One full cycle of IVF takes about three to four weeks. Sometimes these steps are split into different parts, and the process can take longer.
Is there an age limit for IVF?
Most clinics treat women up to age 45-50 using their own eggs or donor eggs. However, success rates with a woman's own eggs decline significantly after age 40.
What is the very first step to start IVF?
The first step is scheduling a consultation with a reproductive endocrinologist. They will review your medical history, perform blood tests, and conduct a pelvic ultrasound to map out a personalized treatment plan.
How do I know if I need IVF?
IVF is typically recommended if you have blocked fallopian tubes, severe male infertility, diminished ovarian reserve, advanced maternal age, or unexplained infertility after other treatments have failed.
What exactly is In Vitro Fertilization (IVF)?
IVF is a complex series of procedures used to help with fertility or prevent genetic problems and assist with the conception of a child. During IVF, mature eggs are collected from ovaries and fertilized by sperm in a lab.
Still have questions?
Can't find the answer you're looking for? Please chat with our friendly team.
Contact Us